Friability of all brands was less than 1% and no significant differences in disintegration times as they disintegrated within 15 minutes. All the brands comply the requirements of Pharmacopoeia as they showed acceptable weight variation range. UV-spectrophotometer was used to determine the percentage released and assay at 218 nm. Then the in-vitro dissolution test, potency, disintegration time were also carried out. Different quality parameters like weight variation, hardness, thickness and friability were determined according to established protocols. To assess the quality, eight different marketed brands of Clopidogrel 75 mg tablets available in Yemeni market collected from different pharmacies in Hodeida city. This study was to investigate quality control parameters of some marketed Clopidogrel tablets. Quality of drug characterizes the production process and every phamaceutical company strives for it but often it is very difficult to achieve. Clopidogrel is a medication to reduce the risk of heart disease and taken orally.
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